The naked mole rat is well known for its exceptional longevity and cancer resistance But just how it achieves this uniquely resilient aging phenotype still presents many open questions Not a mole, not a rat These beauties might not win any pageants, but they are fascinating. Mammals are generally considered to follow something called the gompertz law of mortality, which states that death rate increases with age Naked mole rat, (heterocephalus glaber), burrowing member of the rodent family bathyergidae, named for its wrinkled pinkish skin and hairless bodily appearance.
• they have a low metabolic rate compared to other mammals, an adaptation for life in an environment with limited food resources. In people, cgas suppresses dna repair In naked mole rats, it appears to enhance the ability to repair genetic damage related to aging Jiang and mao’s team pinpointed a difference in four amino acids between human cgas and naked mole rat cgas The variation reduces ubiquitination and degradation of the rodent’s cgas, so the enzyme hangs around longer after dna damage in order to recruit. Escape behaviours are a common response when animals encounter hypoxic environments
