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Circulating endothelial cells (cecs) and bmecs (cbmecs) with a mature phenotype, derived from systemic and bbb vessel turnover, respectively, are increased in patients with systemic inflammation and bbb disorders.

Since the bbb is mainly constituted by the specific endothelial cells, called bmecs, it seems plausible that circulating bmecs (cbmecs) could be biomarkers for bbb dysfunctions. This article is based on current research, according to the sequence of e Severe bacteremia, adhesion and invasion to brain microvascular endothelial cells (bmec), rearrangement of cytoskeleton. Proteomics combined with mechanistic studies indicate that cbmecs are important indicators of bbb/cns disorders in severe hfmd. In addition to providing a system for studying the unique cell biology of this cell type, brain microvessel endothelial cells are readily available for studying general microvessel endothelial cell properties.