Recent advances and prospects concerning the translation of msc techniques into clinical practices will also be discussed. Clinical trials of mesenchymal stromal cell therapies reveal a challenging heterogeneous landscape, including diverse therapeutic targets, patient categories, cell sources, and potential mechanisms of action. In this review, we intend to address some problems and critically discuss the complex nature of mscs in the context of their effective and safe applications in regenerative medicine in different diseases including graft versus host disease (gvhd) and cardiac, neurological, and orthopedic disorders Advances in stem cell technology offer new possibilities for patients with untreated diseases and disorders In summary, application of mscs in the setting of trauma and coagulopathy presents unique opportunities and challenges that have received comparatively little attention to date. In this review, we shed light on challenges and recent advances surrounding stem cell therapies for wound healing and discuss limitations for their clinical adoption
The lack of comprehensive understanding regarding msc stemness greatly hampers the translation of research findings into successful clinical application due to unclear mechanism of action.
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